INDUZIEREN EINZELLERPROTEINE MUTATIONEN?

Abstract

Single cell protein (SCP) - a product containing 80 % raw protein obtained from bacteria grown on a methanol substrate - was tested for mutagenicity in 5 in vivo tests in different mammalian species. The animals were fed either a standard laboratory diet, a semi-synthetic diet, diets containing 12.5 and 25 % SCP or pure SCP. The following investigations were carried out: dominant-lethal-test; host-mediated assay; micronucleus test; chromosome studies in bone marrow celis;4in vivo sister chromatid exchange test. The statistical evaluation of all test results did not reveal any evidence for mutagenic activity of the SCE,