SYNTHESIS AND CHARACTERIZATION OF A SET OF FOUR DODECADEOXYRIBONUCLEOSIDE UNDECAPHOSPHATES CONTAINING 0°-METHYLGUANINE OPPOSITE ADENINE, CYTOSINE, GUANINE, AND THYMINE

Gaffney, B. L.; Marky, L. A.; Jones, R. A.

dc.contributor.author	Gaffney, B. L.
dc.contributor.author	Marky, L. A.
dc.contributor.author	Jones, R. A.
dc.date.accessioned	2023-04-26T08:52:42Z
dc.date.available	2023-04-26T08:52:42Z
dc.date.issued	1987
dc.date.submitted	2023-04-26
dc.identifier.citation	Chemical synthesis in molecular biology, 75 ff	en_US
dc.identifier.issn	0930-4320
dc.identifier.uri	http://hdl.handle.net/10033/623361
dc.description.abstract	A set of four self-complementary dodecanucleoside undecaphosphates, d[CGNGAATTC(O6Me)GCG] (1), where N = A, C, G, or T, has been synthesized by a phosphoramidite procedure. Each sequence forms a stable duplex, with a Im between 19 and 26°C lower than the Tm Of the "parent" molecule d(CGCGAATTCGCG). The lowest melting sequence is the N=T molecule; the overall order is N = C>A>G> T. Enus 0°-met hylation of guanine creates a region of localized instability in DNA regardless of the base opposite the lesion.	en_US
dc.language.iso	en	en_US
dc.relation.ispartofseries	GBF Monographs, Vol. 8	en_US
dc.rights	Attribution-NonCommercial-ShareAlike 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	SYNTHESIS AND CHARACTERIZATION OF A SET OF FOUR DODECADEOXYRIBONUCLEOSIDE UNDECAPHOSPHATES CONTAINING 0°-METHYLGUANINE OPPOSITE ADENINE, CYTOSINE, GUANINE, AND THYMINE	en_US
dc.type	Book chapter	en_US
dc.type	conference paper	en_US
dc.contributor.department	Department of Chemistry Rutgers, The State University of New Jersey New Brunswick, NJ 08903 USA	en_US
dc.identifier.journal	Chemical synthesis in molecular biology	en_US
refterms.dateFOA	2023-04-26T08:52:42Z