BUILDING BLOCKS FOR THE CHEMICAL SYNTHESIS OF DNA CONTAINING C(3')-CH2-P BONDS
Abstract
The preparation, starting from glucose, of 3'-[ (2-chlorophenoxy)phosphinylmethyl]- N2-isobutyryl-5'-0-(4-methoxytrityl)-2' ,3'-dideoxyguanosine ts described. Applying established phosphotriester methods, 21 was used to synthesize a phosphonate analogue of the dinucleotide monophosphate d(G-C).Citation
Chemical synthesis in molecular biology, 107 ffAffiliation
GBF, Gesellschaft fiir Biotechnologische Forschung mbH., Mascheroder Weg 1 D-3300 Braunschweig, F.R.G.Type
Book chapterconference paper
Language
enSeries/Report no.
GBF Monographs, Vol. 8ISSN
0930-4320Collections
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