SYNTHESES OF COMPLEX OLIGOSACCHARIDE SEQUENCES OF GLYCOCONJUGATES

Abstract

The methods of chemically synthesizing complex oligosaccharides have made amazing progress in the past few years. The three basic reactions, especially suited for the selective linking of saccharide units, are characterized. In particular, examples of syntheses, which deal with the construction of oligosaccharide chains from the area of glycolipids and oand N-glycoproteins, are presented. The new methods of conformation analysis are explained, exemplified by an octasaccharide structure. Information concerning the molecular form of an oligosaccharide is given.