Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Birr, ChristianIssue Date
1987Submitted date
2023-04-26
Metadata
Show full item recordAbstract
The development of suitable synthetic peptide vaccines depends both on the search for antigenic determinants in a given bacterial, viral or parasitic antigen and for immunologically acceptable carrier molecules for those antigenic determinants. This encounters a series of problems which are briefly discussed: synthesis of peptide antigens mainly made up from trifunctional amino acids, finding of antigenic determinants, which on immunization cause antibodies that recognize and precipitate not only the synthetic determinant but also the whole native antigen of which the determinants are just a few epitopic entities, construction of immunologically useful polymeric carrier molecules to which the synthetic antigenic determinants can be bonded in a well-defined and reproducible fashion, conformational considerations, which might become essential when a suitable epitope of a native antigen is substracted from its shape - inducing parent environment and, last not but not least, human health care aspects with respect to the applicability of results obtained from synthetic peptide vaccine developments for veterinarian diseases.Citation
Chemical synthesis in molecular biology, 217 ffAffiliation
ORPEGEN , Med.-Molekularbiol. Forschungsgesellschaft m.b.H. Werderstrasse 35, 6900 Heidelberg F.R. GermanyType
Book chapterconference paper
Language
enSeries/Report no.
GBF Monographs, Vol. 8ISSN
0930-4320Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International