IMPLANTABLE GLUCOSE SENSOR - PROBLEMS AWAITING SOLUTIONS FOR LONG-TERM CLINICAL APPLICATION

Abstract

We developed an indwelling, exchangeable and disposable glucose sensor. For preserving excellent in vivo characteristics and extending sensor longevity, the most crucial points are the elegant membrane design and the software backup system. We have developed a band path filter, which was effective in eliminating several types of electrical noises evoked by muscle works or electrical disturbances. The new glucose sensor covered by alginate-polylysine-alginate membrane as a biocompatible one could preserve the sensor activity for 14 days after implantation in subcutaneous tissue of normal dogs. These data indicated that further improvements in membrane design might augment the long-term clinical applicability of glucose sensor.