IMMUNOSENSOR SYSTEMS USING LIPOSOMES AND PLANAR LIPID BILAYER MEMBRANES FOR ION-CHANNEL MODEL SENSORS

Abstract

For the purpose of constructing a new biosensor which mimics the concept of "ion-channel", two approaches were examined: l)liposome systems, and 2)planar lipid bilayer membrane systems. In both cases, some interaction such as immunoreaction, electrostatruneh dıpole,sand hydrophobic interaction of a stimulus with a model receptor site at the surface of lipid membranes triggers the change in permeation of marker ions across the lipid bilayer membranes. This change in permeation of the marker ions is subsequently monitored electrochemically, which is a direct but much amplified measure of the analyte to be assayed.