MEMBRANE DESIGN OF GLUCOSE SENSOR FOR LONG-TERM CLINICAL USE - APPLICATION OF ALGINATE-POLYLYSINE-ALGINATE MEMBRANE -

Abstract

For extending sensor longevity, we coated the alginate-polylysinealginate membrane on the needle-type glucose sensor. The glucose sensor could determine the whole blood glucose concentration directly and preserve the sensor activity for 14 days after implantation. These data indicated that further improvements in membrane design might augment the long-term clinical applicability of glucose sensor.