TOWARDS THE CONSTRUCTION OF NEW PROTEINS

Abstract

The construction of new proteins is a challenging goal in present peptide and protein chemistry (2). Success in the chemical synthesis of de novo designed small proteins has been limited until now because of our still limited knowledge of the factors that determine the folding of a polypeptide chain. We have proposed a new strategy which aims at avoiding this problem by the use of the specific possibilities of peptide chemistry, for the synthesis of template— assembled synthetic proteins (TASPs).