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dc.contributor.authorWingender, Edgar
dc.contributor.authorBercz, G.
dc.contributor.authorHellstern, H.
dc.contributor.authorSchlüter, K.-D.
dc.contributor.authorMayer, H.
dc.date.accessioned2023-11-03T10:42:35Z
dc.date.available2023-11-03T10:42:35Z
dc.date.issued1989
dc.date.submitted2023-11-03
dc.identifier.citationAdvances in protein design, 167 - 176en_US
dc.identifier.isbn0895739534
dc.identifier.isbn3527280243
dc.identifier.issn0930-4320
dc.identifier.urihttp://hdl.handle.net/10033/623532
dc.description.abstractParathyroid hormone (PTH) is the main regulator of calcium homeostasis and controls resorption as well as formation of bone. We assayed overlapping PTH fragments for their capability to stimulate either adenylate cyclase activity or DNA synthesis in in appropriate renal or skeletal cell systems. From these studies we concluded that PTH-induced enhancement of cellular cAMP levels and of cell proliferation are exerted by different functional domains of the hormone molecule. Their conincidence with structural domains will be discussed. After establishment of an efficient expression system for human PTH in E. coli both functional and structural considerations lead to a series of hormone variants. Their biological characterization showed that individual PTH effects could selectively be affected by these mutations. Therefore, site-directed mutagenesis conceivably opens up the possibility to select for either anabolic or catabolic in vivo activities of PTH. Functional design of a potent inducer-of bone growth might be of considerable clinical interest.en_US
dc.language.isoenen_US
dc.publisherGBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweigen_US
dc.relation.ispartofseriesGBF monographs ; Volume 12en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSTRUCTURE-FUNCTION RELATIONSHIP IN PARATHYROID HORMONEen_US
dc.typeBook chapteren_US
dc.typeconference paperen_US
dc.contributor.departmentGBF, D-3300 Braunschweigen_US
dc.identifier.journalAdvances in protein design, 1988en_US
refterms.dateFOA2023-11-03T10:42:36Z


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Attribution-NonCommercial-ShareAlike 4.0 International
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