BIOSENSORS WITH FLUORIDE ION SENSITIVE FIELD EFFECT TRANSISTORS

Abstract

Enzyme field effect transistors for Qlucose and lactate were developed by coupling a new transducer type, the fluoride ion sensitive FET, with the peroxidase-catalyzed reaction liberating fluoride ions from organo-fluoro compounds in the presence of hydrogen peroxide “which was produced in coupled oxidase reactions. Glucose oxidase or lactate oxidase and peroxidase were coimmobilized with human serum albumin or polyurethan at a multigate pF-FET. 4-fluoroaniline and pentafluorophenol were used as organo-fluoro compounds. The main functional parameters are given.