BIOEXPERIMENTS WITH IMPROVED CHEMOSTAT METHODOLOGY

Abstract

Developments in bioprocess control include improvement of online measurements and control. Accuracy and precision of control or availability of the chemostat systems have reached a very high level. Measurement and control is based on new software concepts providing automatic control of complex physiological investigations or bioprocess development work. Results from cell cyele studies on yeasts synchronized growth, repetitive batch methods, medium design and integrated process layout for the production of rhamnolipids and enantiomerically pure compounds are reported. It is concluded that the breakthrough described in combination with FIA-coupling are the prerequisites for in vivo studies of the livingcells.