MEMBRANE PROTEIN RECEPTORS IN SUPPORTED LIPID BILAYERS AS BIOSENSORS

Abstract

Acetylcholine receptors have been incorporated into planar lipid bilayers and coupled to the surface of a silicon wafer. The binding of ligands to these receptors have been quantified by measuring the concomitant changes of certain electrical properties of the membrane such as impedance and capacitance. The results show that there is principle feasibility to use membrane protein receptors as biosensors.