Statistical Analysis of DNA Sequences

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Authors
Herzel, Hanspeter
Ebeling, Werner
Grosse, Ivo
Schmitt, Armin O.
Issue Date
1995
Submitted date
2024-05-29

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Abstract
Wereport recent results of statistical analysis of DNA sequencesin this paper. First, we show howrepetitive segments reduce the information content measured by Shannon entropies. Then, the effect of a nonuniform codon usage on the mutual information function is studied analytically. For this purpose, the concept of pseudo-exons is introduced. Finally, we discuss the modularity of DNA which can serve as a sensitive tool to distinguish DNA sequences from randomstrings.
Citation
Bioinformatics - from nucleic acids and proteins to cell metabolism, 29 - 45
Affiliation
Institute of Theoretical Physics, Technical University, Hardenbergstr. 36, D-10623 Berlin, Germany; Institute of Physics, Humboldt-University, Invalidenstr. 110, D-10115 Berlin, Germany; Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Publisher
GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
Journal
Bioinformatics - from nucleic acids and proteins to cell metabolism, 1995
URI
http://hdl.handle.net/10033/623848
Type
Book chapter
conference paper
Language
en
Series/Report no.
GBF monographs ; Volume 18
ISSN
0930-4320
ISBN
3527300724
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