Browsing Publications of Dept. Medizinische Mikrobiologie (MMIK) by Subject (MeSH)
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Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions.Pseudomonas aeruginosa causes lung infections in patients suffering from the genetic disorder Cystic Fibrosis (CF). Once a chronic lung infection is established, P. aeruginosa cannot be eradicated by antibiotic treatment. Phage therapy is an alternative to treat these chronic P. aeruginosa infections. However, little is known about the factors which influence phage infection of P. aeruginosa under infection conditions and suitable broad host range phages.
Sequencing and characterization of Pseudomonas aeruginosa phage JG004.Phages could be an important alternative to antibiotics, especially for treatment of multiresistant bacteria as e.g. Pseudomonas aeruginosa. For an effective use of bacteriophages as antimicrobial agents, it is important to understand phage biology but also genes of the bacterial host essential for phage infection.