• DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4).

      Quentmeier, Hilmar; Eberth, Sonja; Romani, Julia; Weich, Herbert A; Zaborski, Margarete; Drexler, Hans G; Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. (2012-01-17)
      Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells. This study was performed to examine whether VEGF-R2 (KDR) and VEGF-R3 (FLT4) are regulated by DNA methylation.